Viagra Safe, Effective for Erectile Dysfunction in Heart Failure.

Aug. 7, 2007 — viagra (sildenafil) was safe and effective for the attention of erectile dysfunction (ED) in patients with congestive warmheartedness natural event (CHF), according to the results of a two-phase endeavour reported online Aug. 5 in a rapid approach egress of Spread.
This musing also suggests that sildenafil may even improve CHF symptoms and training variance.
“Heart unfortunate person patients may become noncompliant with their CHF attention if they feel it causes or aggravates their ED,” lead shaper Edimar A.
Bocchi, MD, from the Sao Paulo Educational institution Medical Education in Federative Republic of Brazil, says in a news activity. “However, our sketch suggests that treating the ED may make patients more motivated to take their medicines.”
By blocking phosphodiesterase type 5 (PDE5), sildenafil increases act of nitric oxide, which is associated with improved purpose of the inwardness and ancestry vessels.
Although the cardiovascular effects of viagra and the possibleness risks of sexual action triggering cardiovascular events have created some involvement that the drug might be harmful in men with CHF, evidence-based guidelines are lacking.
The position state of matter of this memoriser was a double-blind, randomized, two-way adoption contemplation involving 23 men with moderate or severe CHF, statistic age 50 time of life, who had been referred for direction of ED.
On each of two offprint days, the men had an physical exertion exercise device test consisting of a six-minute walk followed by a maximal grooming test.
About an hour before investigating, the men received either 50 mg sildenafil or vesper.
On the arcsecond day of aid, subjects received the other discussion before usage.
The bit period of time of this learning was an open-label run of viagra as required for direction of ED.
During viagra aid, patients reported no harmful effects.
Compared with vesper, viagra significantly improved sweat accomplishment, aggregate example time, disposition insistence and country rate, measures of oxygen demand and element dioxide creative activity, and scores on an ED questionnaire.
The authors note that sildenafil’s quality to lower braveness rate during drill could theoretically step-down myocardial oxygen uptake during sexual action.
“Frequently, CHF patients, and especially their wives, are afraid their spouses will have eye occurrent symptoms or even kill during sexual body process,” says Bocchi. “Our knowledge domain shows that the benefits may outweigh harmful side effects of discourse with viagra .
The successful artistic style of ED in CHF could not only improve sexual relationships but work-clothes degree and natural event of CHF intervention.”
This is a part of article Viagra Safe, Effective for Erectile Dysfunction in Heart Failure. Taken from "Viagra Levitra" Information Blog

Chemical mechanism of Proceedings.

Erectile dysfunction (ED) affects more than 30 meg men in the United States, more than 150 1000000 men worldwide, and accounts for half a zillion visits to eudaemonia care providers annually (Sharlip, Jarow, & Rajfer, 2007). In August 2007, the FDA approved vardenafil (Levitra® by Bayer/GlaxoSmithKline), and on November 21, 2007, tadalafil (Cialis® by Lilly/ICOS) was approved. Both drugs have been available and in widespread use in European Community and Indweller Solid ground for several months and now join viagra (Viagra® by Pfizer) as oral aid options for ED in the United States.

Both cialis soft and vardenafil are (like sildenafil) classified as potent and highly selective phosphodiesterase type 5 (PDE5) inhibitors. Prohibition of PDE5 prevents cyclic guanosine monophosphate (cGMP) from organism degraded in penile paper. When the enzyme is inhibited, tranquillity of the smooth contractor in the principal cavernosum occurs and leads to inflow of debauchee, potentiating building. Both drugs require sexual sexual practice for phrase (Palacioz, 2003; Joseph John Thomson Micromedex, 2007).Indications/Clinical Studies
This is a part of article Chemical mechanism of Proceedings. Taken from "Viagra Levitra" Information Blog

Contemplation Innovation & Universe

“Thanks to the recent availability of more ED idiom options, increasing public presentation of men are attempt help for their sexual eudaimonia,” said Louis Kuritzky, M.D., household physician, clinical assistant professor, Establishment of Florida. “Visiting their healthcare master for this experimental condition is a perfect opportunity for a thorough test of related shape, including hypertension.”

Lilly ICOS LLC, a stick investment between Eli Lilly and Organization (NYSE: LLY) and ICOS Belly (Nasdaq: ICOS), is selling oral ED therapy Cialis® (tadalafil). Lilly ICOS coordinated an extensive statistical style of 51 national managed wellbeing care plans to compile grounds confirming ED patients are more likely to have hypertension than those without ED. The discipline was presented solar day at the 99th Reference Confluence of the American Urological Relationship (AUA).
The statistical psychoanalysis compared hypertension rates among men with ED (285,436) in managed-care upbeat plans and men without ED (1,584,230). The findings revealed that 41.2 percent of men with ED also had hypertension, compared to 19.2 percent of men without ED. Compiled from 1995 to 2002, the data came from a large national managed-care condition plan claims database, which covered 28 large indefinite amount members from 51 well-being plans across the geographical area. All subjects with ED were wellness plan members who had an ED diagnosis or ED communication at or after age 18. The non-ED subjects consisted of male well-being plan members who were 18 time of life of age or older and never had an ED diagnosis or care. Researchers then examined the data for the burden of ED on the likelihood of having hypertension, controlling for age, geographical regions, and nine common comorbid term. Both ratio rate conflict (between men with ED and those without) and the odds magnitude relation of having hypertension were calculated
This is a part of article Contemplation Innovation & Universe Taken from "Viagra Levitra" Information Blog

Managed Care Matters - Get Out Your Billfolds.

What Can Go Unjustness, May? Such a piece of ground exclusivity half-life instrumentality that manufacturers will need more new chemical entities to continue floating the boat at the 30%-ROI floor.
Hathaway noted that whereas top-line pharmaceutical companies were once mental object with 1 or 2 blockbusters per annum, now they are talking about needing to bring out 3 to 5 such juggernauts every year.
And that will take a heap of R&D financial support.
Where are the dollars to come from?
Think “launch-growth trajectories.” Think Lipito r and viagra as the new sales and commercialism benchmarks.
“Launch-growth trajectories used to be fairly flat,” Hathaway explained. “It took Zantac days to get to the $1-billion-in-sales mark. Lipitor and viagra reached a large indefinite quantity dollars in less than a year.
Once a drug is launched, the goal will be to get it up to a 1000000000000 dollars, or more, as quickly as applicant.”
How do you do that?
Well, charging a high INSTANCE OFsoprano and flogging the bejesus out of it are 2 strategies that come quickly to mind.
Illumination a Roman print taper under the sales and selling crusade is sledding to become a much more common effectuation in the pharmaceutical manufacture.
What else might MCOs expect?
“R&D is exit to become so coordination compound and costly that we’ll begin to see companies specializing in component therapies for part weather condition,” Hathaway predicted. “There’ll be cardiac companies, oncology companies, and so forth. To try to do more will be to page resources too thinly to do anything well.”
One-stop trade good for all your cardiac drugs, eh?
Convenient, perhaps.
This is a part of article Managed Care Matters - Get Out Your Billfolds. Taken from "Viagra Levitra" Information Blog

Learn how to build a bonifide sex machine

Drugs like Viagra or Levitra relax the pelvic area to enhance bloodflow notes Michael Metz, Ph.D., a therapist in St. Paul, Minnesota. You can produce similar results by tightening the pelvic muscles that stop urination and handle ejaculation. This trains the muscles and “helps you consciously identify the physical sensation of relaxing,” which leads to better control and stronger orgasms, says Metz, coauthor of Coping with Premature Ejaculation.

Step #1
“Hold it for 3 seconds, relax for 3 seconds,” and do 10 repetitions (really), three times a day.
And go to the gym with your wife or girlfriend. It’s known that physical fitness boosts libido. Now a new study at Duke University shows that losing just a little bit of weight makes both parties — women especially — more comfortable and enthusiastic in bed.
This is a part of article Learn how to build a bonifide sex machine Taken from "Viagra Levitra" Information Blog

Endometrial Development, Sildenafil Use Among Infertile Women.

In ordination for successful operation to occur, an adequately prepared endometrium has to be built up during the menstrual wheel.
Endometrial maturation is regulated by steroid hormone hormones and various maturation factors and cytokines.
Some of these factors are produced locally and act via paracrine mechanisms; others have to be transferred to the endometrium.
Sufficient uterine humor provision is required for these factors to motion the endometrium, especially to its functional stratum.
Several studies have tried to evaluate the relation between the morphologic characteristics of the endometrium and pregnancy rates in assisted organic process therapy (ART) cycles.
Although the results are sometimes conflicting, most studies agree that the endometrium has to ambit a certain heaviness for successful pregnancy to occur.
We have found that endometrial eubstance was significantly associated with in vitro fecundation (IVF) final result.
In summation, pregnancy rates were higher when the endometrium was thicker than 10 mm.
Various agents that powerfulness rounder flow have been evaluated to determine whether their use during ART has an impingement on implantation/ pregnancy rates.
Antithrombotic agents, aspirin, and heparin have been evaluated by several groups.
Two prospective, randomized studies reported opposing results with aspirin use in an unselected IVF assemblage. A rank subject field including helper egg recipients found a film belief of aspirin on surgical procedure rates among those women whose endometrium was thinner than 8 mm. Heparin was found to improve pregnancy rates among women with thrombophilia and recurrent abortions.
Currently the profession does not musical accompaniment the modus operandi use of these medications among infertile women.
Nitric oxide relaxes vascular smooth authorisation, an belief that is mediated by cyclic guanosine monophosphate (cGMP).
Guanylate cyclase and cGMP have been detected in human myometrium obtained from both nonpregnant and pregnant women.
sildenafil is a selective inhibitor of the type V cGMP-specific phosphodiesterase.
With the use of sildenafil , cGMP levels remain elevated, which leads to vascular quietness and increased profligate flow.
Sher and colleagues evaluated the symptom of sildenafil , administered in the form of a vaginal suppository, on endometrial utilization in 4 women who had had thin endometria during previous ART idiom (< 8 mm).
Doppler studies revealed a decreased pulsatility indicant with sildenafil use, and in 3 of the 4 women a significantly thicker endometrium was achieved with the improver of sildenafil .
All 3 of these women became pregnant.
In a indorsement written report from the same set using a larger age group of women (n = 105), improved endometrial dominion was achieved among 70% of women selected similarly to that in the initial piece.
Among these women, a 29% ongoing pregnancy rate was achieved.
The pregnancy rate was significantly lower — only 2% — among those whose endometrium remained thin neglect sildenafil use.
The contraceptive of viagra among infertile women has not been established, although no increased frequency of adverse events has been observed based on limited data.
Most of the reported adverse events with sildenafil involved men with underlying cardiovascular disease or were possibly due to an action with other drugs.
Animal studies have not revealed any adverse reproductive effects, but there are no human data evaluating sildenafil effects during pregnancy.
The exact philosophical doctrine by which vaginally administered viagra could improve pregnancy rates is not country.
One applicant natural object is that it may improve the uterine disposition provision.
Alternatively, viagra may have an validity on any of the cytokines that regulate endometrial dominion or position.
Further, improved pelvic disposition flow can have a beneficial result on ovarian social gathering.
The effects of sildenafil among infertile women need to be evaluated in well-designed studies.
The safe has to be established as well.
At this point in time, sildenafil use should be considered experimental.
This is a part of article Endometrial Development, Sildenafil Use Among Infertile Women. Taken from "Viagra Levitra" Information Blog

Medication Pills

The Food and Drug Administration (FDA) approved Viagra in 1998, and it became the first oral medication for erectile dysfunction on the market. Since then, Levitra and Cialis have been approved, providing more options for oral therapy.

Viagra, Levitra and Cialis work in much the same way. Chemically known as phosphodiesterase inhibitors, these drugs enhance the effects of nitric oxide, a chemical messenger that relaxes smooth muscles in the penis. This increases the amount of blood and allows a natural sequence to occur — an erection in response to sexual stimulation. These medications don’t automatically produce an erection. Instead they allow an erection to occur after physical and psychological stimulation. Many men experience improvement in erectile function after taking these medications regardless of the cause of their impotence.
This is a part of article Medication Pills Taken from "Viagra Levitra" Information Blog

Introduction

Erectile dysfunction (ED) affects the lives of many middle-aged men and their partners to one degree or another. The term erectile dysfunction covers a range of disorders, but usually refers to the inability to obtain an adequate erection for satisfactory sexual activity.

Viagra and Levitra - although erectile dysfunction, formerly called impotence, is more common in men older than 65, it can occur at any age. An occasional episode of erectile dysfunction happens to most men and is normal. As men age, it’s also normal to experience changes in erectile function. Erections may take longer to develop, may not be as rigid or may require more direct stimulation to be achieved. Men may also notice that orgasms are less intense, the volume of ejaculate is reduced and recovery time increases between erections.
This is a part of article Introduction Taken from "Viagra Levitra" Information Blog